LEGO 2025 meeting
Machine Learning for Genomics
November 27th-28th
Nantes, GDR BIMMM days

Planning

Thursday, November 27, 2025

Time Event
09:30 - 09:45 Introduction  
09:45 - 11:00 Deep Learning for Structural Data  
09:45 - 10:30 › Rationalizing machine learning on biomolecules structures, applications to RNA therapeutics and PPI predictions - Vincent Mallet, Centre de Bioinformatique  
10:30 - 11:00 › DLScaff: Deep Learning for Hi-C Assembly Correction and Scaffolding - Alexis Mergez, Unité de Mathématiques et Informatique Appliquées de Toulouse  
11:00 - 11:30 Coffee break  
11:30 - 12:30 Interpretability and Transfer Learning in Transcriptomics  
11:30 - 12:00 › A Biologically Interpretable Approach To Identify New Therapeutics Targets Using Deep Neural Networks - Charlotte Job, Informatique, BioInformatique, Systèmes Complexes  
12:00 - 12:30 › Adversarial Domain Adaptation Enables Knowledge Transfer Across RNA-Seq Datasets - Kevin DRADJAT, Informatique, BioInformatique, Systèmes Complexes (IBISC)  
12:30 - 14:15 Lunch  
14:15 - 15:30 Phylogenetics and Phylodynamics  
14:15 - 15:00 › Estimating factors of epidemic spread with deep learning-enabled phylodynamics - Anna Zhukova, Institut de biologie de l'ENS Paris, Institut Pasteur  
15:00 - 15:30 › Graph Neural Networks for Likelihood-Free Inference in Diversification Models - Amélie Leroy, Biologie Computationnelle, Quantitative et Synthétique, Modélisation de la Biologie  
15:30 - 16:00 Coffee break  
16:00 - 16:30 Phylogenetics and Phylodynamics  
16:00 - 16:30 › Likelihood-free inference of phylogenetic tree posterior distributions - Luc Blassel, Biologie Computationnelle, Quantitative et Synthétique [Paris] (ex LCQB)  
16:30 - 17:00 Representation Learning in (Epi)genomics  
16:30 - 17:00 › Spreading of methylation of transposable elements in A.Thaliana - Ekaterina Antonenko, CBIO-Centre for Computational Biology, U1331, Institut Curie, PSL-Research University  
17:00 - 17:30 Closing remarks  

Friday, November 28, 2025

Time Event
09:00 - 09:10 Introduction - Raphael Mourad  
09:10 - 10:00 LLM metagenomics - Jean-Daniel Zucker  
10:00 - 10:20 CRE in plant genomics - Marie-Laure Martin and Sylvie Coursol  
10:20 - 10:40 Deep learning plant genomics - Mikael Lucas  
10:20 - 11:40 Deep learning for farm animal genomics - Raphaël Mourad  
10:40 - 11:00 Coffee break  
11:00 - 11:20 Feedback on Evo2 - Guillaume Gautreau  
11:40 - 12:00 Foundation model multiscale - Jérémie Kalfon  
12:00 - 12:20 Deep learning for 3D genome - Thomas Faraut  
12:30 - 13:30 Lunch  
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